American Dictionary
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to stop talking or making a noise
Why don't you shut up?
I wish he'd shut up about his vacation.
to make someone stop talking or making a noise
Can't you shut the kids up for just five minutes?
to keep someone in a small area for a specific purpose
Many students shut themselves up in their rooms to study.
to close a building so that people cannot enter or leave it
to close a business, either permanently or at the end of the working day